Does CBD oil interact with anti-inflammatory drugs?
Taking a nonsteroidal anti-inflammatory drug (NSAID) such as ibuprofen, diclofenac or ketoprofen along with CBD may increase the risk of liver problems and gastrointestinal upset. This is especially true if you take these medications regularly or take high doses of each. More info
The most common DDIs between NSAIDs and CBD are related to the CYP enzymes responsible for the metabolism of these drugs, particularly CYP2C8 and CYP2C9. In vitro data have shown that CBD decreases the activity of both CYP2C8 and CYP2C9, which is an important consideration when considering a patient’s use of NSAIDs with CBD.
If you are taking NSAIDs, talk with your doctor about whether or not to start taking CBD at the same time. If you do take CBD with ibuprofen, you should space out your dosages and avoid taking both at the same time.
CBD Oil and NSAIDs: Can They Be Used Together Safely
Interactions with blood-thinning medicines like Warfarin or Valproic Acid are also possible. These drugs can raise abnormally high levels of liver enzymes and cause tiredness when taken with CBD.
Beta-blockers, such as metoprolol, lower blood pressure by changing the way epinephrine is released. They can cause side effects such as dizziness, nausea and stomach pain when they are combined with CBD.
Rifampin, a drug used to treat tuberculosis, can also cause adverse reactions when taken with CBD. These may include nausea, vomiting, abdominal pain and cold hands and feet.
As with all medicines, it is recommended that you discuss any new treatment plans with your doctor or pharmacist before starting any new medication. There are a number of ways to ensure that CBD is safe for you, such as using products from reputable companies and following the instructions for proper dosing.